Parameter values used and the result for the prediction of the decrease in MDZ CLint using single point estimate (eq. 10)
| Parameters | Values |
|---|---|
| fm of MDZ | 0.95 |
| Mean time-averaged ERY concentration (μM) | 54.5 |
| fu of ERY | 0.15 |
| kinact (min−1) | 0.04 |
| KI (μM) | 15.1 |
| kdeg (h−1) | 0.03 |
| Prediction results | |
| Predicted MDZ CLint′/CLint | 0.075 |
| Predicted -fold increase in MDZ exposure | 15.4 |