Uptake Clearance | Metabolic Clearance | Overall Intrinsic Clearance | |||
---|---|---|---|---|---|
PSinf,MIDa | PSinf,vitrob | CLmet,int,vitroc | CLint,all,vivod | ||
ml/min/g liver | |||||
Pravastatin | 6.48 ± 0.06 | 2.59 ± 0.14 | 0.793e± 0.020 | 6.9–11 | |
Pitavastatin | 91.5 ± 8.5 | 53.3 ± 8.3 | 0.619 ± 0.434 | 42–53 | |
Atorvastatin | 42.1 ± 5.3 | 23.1 ± 2.5 | 0.910 ± 0.056 | 26–38 | |
Fluvastatin | 126 ± 12 | 29.2 ± 2.0 | 2.71 ± 0.24 | 85–154 |