TABLE 2

Comparison of KI and kinact for clarithromycin

SourceKIkinactReference
μMh−1
Human liver microsomes5.494.32Mayhew et al., 2000
CYP3A4 + b5 Supersomes4.1213.8Jones et al., 2007
Human liver microsomes37.0–41.42.5–2.8Ito et al., 2003
Recombinant CYP3A4a2.252.4Polasek and Miners, 2006
Human liver microsomesa29.53.0Polasek and Miners, 2006
In vivo estimate5.30.4 (liver); 4 (intestine)
  • a Determined by 6β-hydroxylation of testosterone.