Drugs | Species | Rb | Papp | Protein Binding | fp | fb | CLintliver | CLintintestine | fb*CLintliver/Qh | ATPase |
---|---|---|---|---|---|---|---|---|---|---|
×10−6cm/s | % | ml/min/kg | μ l/min/mg protein | ratio vs VER | ||||||
Hydrochlorothiazide | Human | 2.70 | 0.1 | 40.0 | 0.600 | 0.222 | −a | −a | −a | 0 |
Monkey | 1.84 | 39.0 | 0.610 | 0.331 | −a | −a | −a | NT | ||
Dexamethasone | Human | 0.95 | 16.4 | 52.0 | 0.480 | 0.507 | 66 | −a | 1.62 | 0.01 |
Monkey | 1.34 | 77.5 | 0.225 | 0.167 | 24 | −a | 0.09 | NT | ||
Nifedipine | Human | 0.74 | 13.4 | 93.4 | 0.066 | 0.089 | 438 | 138 | 1.89 | 0.03 |
Monkey | 0.65 | 94.3 | 0.057 | 0.088 | 2597 | 612 | 4.96 | NT | ||
Midazolam | Human | 0.69 | 30.8 | 97.0 | 0.030 | 0.044 | 877 | 385 | 1.85 | 0.28 |
Monkey | 0.77 | 95.7 | 0.043 | 0.056 | 1422 | 1635 | 1.72 | NT | ||
Quinidine | Human | 0.72 | 17.9 | 91.4 | 0.086 | 0.119 | 52 | −a | 0.30 | 4.57 |
Monkey | 0.78 | 92.1 | 0.079 | 0.102 | 872 | 212 | 1.91 | NT | ||
Tacrolimus | Human | 20.00 | 34.2 | 98.9 | 0.011 | 0.001 | 1538 | 625 | 0.04 | 7.89 |
Monkey | 20.00 | 99.0 | 0.010 | 0.001 | 5793 | 4663 | 0.06 | NT | ||
Verapamil | Human | 0.92 | 35.8 | 95.2 | 0.048 | 0.052 | 656 | 69 | 1.65 | 1.00 |
Monkey | 0.93 | 88.2 | 0.118 | 0.127 | 2491 | 696 | 6.83 | NT | ||
Digoxin | Human | 1.00 | 0.1 | 60.3 | 0.397 | 0.398 | −a | −a | −a | 56.1 |
Monkey | 0.82 | 52.9 | 0.471 | 0.574 | −a | −a | −a | NT | ||
Propranolol | Human | 0.89b | 37.4 | 86 | 0.140 | 0.157 | 165 | −a | 1.25 | 1.70 |
Monkey | 0.85c | 78.8 | 0.212 | 0.249 | 974 | −a | 5.25 | NT | ||
Amitriptyline | Human | 0.86d | 53.3 | 85.4 | 0.146 | 0.170 | 80 | −a | 0.66 | 1.20 |
Monkey | 1.40 | 87.2 | 0.128 | 0.091 | 2559 | −a | 5.06 | NT | ||
Timolol | Human | 0.84b | 27.3 | 50.9 | 0.491 | 0.585 | 32 | −a | 0.89 | 1.66 |
Monkey | 1.02 | 95.5 | 0.045 | 0.044 | 391 | −a | 0.37 | NT | ||
Ibuprofen | Human | 0.55d | 29.4 | 98.8 | 0.012 | 0.022 | 38 | −a | 0.04 | 1.14 |
Monkey | 0.61 | 98.5 | 0.015 | 0.024 | 25 | −a | 0.01 | NT |