TABLE 7

Michaelis-Menten kinetic parameters for albendazole S-oxidation by recombinant rCYP2J2 and rCYP3A4 and HLM

KsVmaxKi
μMpmol/min/pmol rP450μM
rCYP2J24.23 ± 1.041.89 ± 0.3019.29 ± 6.56
rCYP3A46.02 ± 1.820.74 ± 0.1368.30 ± 34.95
HLM5.29 ± 0.9374.32 ± 8.80a16.69 ± 3.91
  • a Unit of measure is pmol/min/mg microsomal protein.