Observed and predicted biliary excretion of 50 BMS compounds
r = 0.94 between observation and prediction. The mean of the differences is 0, whereas the mean of the absolute differences is 7.8% of the dose.
| Compound | Observation | Prediction | Difference | Absolute Difference |
|---|---|---|---|---|
| % dose | % dose | |||
| I | 3.0 | −6.4 | −9.4 | 9.4 |
| II | 1.3 | −6.9 | −8.2 | 8.2 |
| III | 1.5 | 13.6 | 12.1 | 12.1 |
| IV | 67.8 | 64.3 | −3.5 | 3.5 |
| V | 0.7 | 5.1 | 4.4 | 4.4 |
| VI | 80.0 | 79.4 | −0.6 | 0.6 |
| VII | 8.6 | 7.4 | −1.2 | 1.2 |
| VIII | 4.0 | 5.3 | 1.3 | 1.2 |
| IX | 83.0 | 70.5 | −12.5 | 12.5 |
| X | 5.2 | 9.6 | 4.4 | 4.4 |
| XI | 0.5 | 5.6 | 5.1 | 5.5 |
| XII | 0.7 | 4.3 | 3.6 | 3.6 |
| XIII | 11.5 | 1.2 | −10.3 | 10.3 |
| XIV | 1.0 | 7.2 | 6.2 | 6.2 |
| XV | 83.9 | 82.5 | −1.4 | 1.4 |
| XVI | 80.2 | 78.0 | −2.2 | 2.2 |
| XVII | 32.4 | 22.3 | −10.1 | 10.1 |
| XVIII | 77.0 | 90.6 | 13.6 | 13.6 |
| XIX | 81.8 | 77.1 | 4.7 | 4.7 |
| XX | 41.4 | 21.3 | −20.1 | 20.1 |
| XXI | 60.0 | 85.6 | 25.6 | 25.6 |
| XXII | 11.9 | 15.5 | 3.6 | 3.6 |
| XXIII | 29.7 | 19.1 | −10.6 | 10.6 |
| XXIV | 2.7 | 21.1 | 18.4 | 18.4 |
| XXV | 63.2 | 34.1 | −29.1 | 29.1 |
| XXVI | 33.0 | 27.5 | −5.5 | 5.5 |
| XXVII | 43.9 | 28.1 | −15.8 | 15.8 |
| XXVIII | 0.1 | 1.9 | 1.8 | 1.8 |
| XXIX | 9.4 | 26.4 | 17.0 | 17.0 |
| XXX | 0.5 | 1.7 | 1.2 | 1.2 |
| XXXI | 10.4 | 24.0 | 13.6 | 13.6 |
| XXXII | 19.7 | 7.8 | −11.9 | 11.9 |
| XXXIII | 27.4 | 22.3 | −5.1 | 5.1 |
| XXXIV | 6.4 | 13.7 | 7.3 | 7.3 |
| XXXV | 30.3 | 27.4 | −2.9 | 2.9 |
| XXXVI | 1.9 | 4.4 | 2.5 | 2.5 |
| XXXVII | 3.7 | 13.3 | 9.6 | 9.6 |
| XXXVIII | 92.1 | 82.8 | −9.3 | 9.3 |
| XXXIX | 0.1 | −2.5 | −2.6 | 2.6 |
| XL | 47.0 | 34.2 | −12.8 | 12.8 |
| XLI | 4.4 | 9.1 | 4.7 | 4.7 |
| XLII | 0.2 | 10.5 | 10.3 | 10.3 |
| XLIII | 8.0 | 10.2 | 2.2 | 2.2 |
| XLIV | 25.5 | 25.2 | −0.3 | 0.3 |
| XLV | 21.7 | 21.4 | −0.3 | 0.3 |
| XLVI | 2.0 | 4.4 | 2.4 | 2.4 |
| XLVII | 20.7 | 31.4 | 10.7 | 10.7 |
| XLVIII | 100 | 95.0 | −5.0 | 5.0 |
| IL | 29.5 | 39.2 | 9.7 | 9.7 |
| L | 0.1 | 4.2 | 4.1 | 4.1 |