TABLE 3

Correlation between the activities for formation of M2, M4, and M7 and the predetermined activities of P450 enzymes in a panel of individual HLM samples

Individual human liver microsomes were incubated at 5 μM apixaban in the presence of NADPH at 37°C for 60 min. The Pearson correlation coefficients (r) of the predetermined CYP3A4/5 activities with the predetermined 2C8 and 2B6 activities were 0.66 and 0.59, respectively.

Enzyme	Correlation Coefficients (r)
Enzyme	M2 Formation	M4 Formation	M7 Formation
CYP1A2	0.14	0.14	0.01
CYP2A6	0.24	0.34	0.38
CYP2B6	0.36	0.46	0.50*
CYP2C8	0.65*	0.42	0.61*
CYP2C9	0.51*	0.31	0.36
CYP2C19	0.25	0.43	0.36
CYP2D6	0.12	0.26	0.39
CYP2E1	0.36	0.03	0.19
CYP3A4/5	0.76**	0.90**	0.96**
CYP4A11	0.26	0.07	0.03

↵* p < 0.05 (t test).
↵** p < 0.01 (t test).