Metabolite pattern in plasma, urine, and feces after a single oral dose of 10 mg (21.2 μmol) of [14C]linagliptin (arithmetic means of six individuals)
| Metabolite | Plasma (1.5 h + 3 + 6 h) | Urine (0–48 h) | Feces (0–120 h) | Urine + Feces (Total) |
|---|---|---|---|---|
| % of sample radioactivity | % of dose | |||
| Linagliptin | 74.2 | 3.9 | 74.1 | 78.0 |
| CD1790 | 16.9 | 0.2 | 0.3 | 0.5 |
| M489(1) | 0.3 | 0.2 | 4.5 | 4.7 |
| M531(1)+M490(1)+ M506(1) | 2.5 | 2.5 | ||
| M665(3) | ||||
| M665(8)+M650(1) | 5.5 | |||
| m4* | 3.1 | |||
| Others (sum) | 1.1** | 0.1 | 1.3** | |
| Total | 100.0 | 5.4 | 81.5 | 87.0 |