Pharmacokinetic Parameters | Healthy Male Volunteers | Sprague-Dawley Rats | Beagle Dogs | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Radioactivity* | Zoniporide | Radioactivity* | Zoniporide | Radioactivity* | Zoniporide | |||||||
Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | |
Tmax (h) | 1.0 | 0.0 | 1.0 | 0.0 | ||||||||
Cmax (ng/ml) | 899 | 237 | 590 | 44.2 | ||||||||
AUC0–tlast (ng-h/ml) | 2925 | 223 | 833 | 33.4 | 3570 | 323 | 1390 | 287 | 3160 | 672 | 2009 | 582 |
AUC0–∞ (ng-h/ml) | 3250 | 122 | 839 | 34.2 | 3650 | 307 | 1490 | 273 | 3330 | 673 | 2370 | 683 |
t1/2 (h) | 6.7 | 3.3 | 2.0 | 0.4 | 2.00 | 0.83 | 0.4 | 0.10 | 2.80 | 0.34 | 2.51 | 0.59 |
Cl (ml/min/kg) | 21.0 | 1.2 | 113 | 22 | 21 | 4.7 | ||||||
Vss (l/kg) | 1.7 | 0.4 | 2.2 | 0.58 | 3.7 | 0.59 |
↵* The radioactivity was expressed as ng-Eq/ml.