Mean pharmacokinetic parameters of total circulating radioactivity and zoniporide in healthy male volunteers, Sprague-Dawley rats, and Beagle dogs after intravenous administration of [14C]zoniporide

Healthy male volunteers were administered [14C]zoniporide by intravenous infusion for 1 h at a dose of 80 mg (100 μCi). The Sprague-Dawley rats and Beagle dogs were administered a bolus of [14C]zoniporide at a dose of 10 mg/kg (50 μCi) and 3 mg/kg (150 μCi), respectively.

Pharmacokinetic ParametersHealthy Male VolunteersSprague-Dawley RatsBeagle Dogs
Tmax (h)
Cmax (ng/ml)89923759044.2
AUC0–tlast (ng-h/ml)292522383333.43570323139028731606722009582
AUC0–∞ (ng-h/ml)325012283934.23650307149027333306732370683
t1/2 (h)
Cl (ml/min/kg)21.01.211322214.7
Vss (l/kg)
  • * The radioactivity was expressed as ng-Eq/ml.