TABLE 4

Percentage of circulating metabolites of zoniporide and their estimated exposure in healthy male volunteers, Sprague-Dawley rats, and Beagle dogs after intravenous administration of [¹⁴C]zoniporide

Healthy male volunteers were administered [¹⁴C]zoniporide by intravenous infusion for 1 h at a dose of 80 mg (100 μCi). The rats were administered a bolus of [¹⁴C]zoniporide at a dose of 10 mg/kg (50 μCi). The dogs were administered a bolus of [¹⁴C]zoniporide at a dose of 3 mg/kg (150 μCi). The estimated exposures were determined by multiplying percent circulating radioactivity_metabolite and AUC_{(0–tlast)radioactivity}. The AUC_{(0–tlast)radioactivity} is depicted in Table 2.