TABLE 2

Analytical solutions for the metabolic (CL_liver,met), excretory (CL_liver,ex), and total (CL_liver,tot) liver clearances in the presence of futile cycling

Clearances^{^a}	With Barrier	Without Barrier (CL_in = CL_ef ≫ CL_int,sec, ef_m″ CL_int,met^D→Mi, and CL_int,met^other)
CL_liver,ex^{^b}
CL_liver,met
CL_liver,tot

↵a The solutions for the total hepatic (CL_liver,tot) and the excretory (CL_liver,ex) clearances were obtained by dose/AUC_R and A_e,∞ /AUC_R, respectively. The metabolic clearance was estimated by the difference of CL_liver,tot and CL_liver,ex.
↵b ef_m″, effective coefficient for metabolite formation, .