AUCI/AUC values obtained from the literature
| Inhibitor (mg/day) | AUCI/AUC | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| BUD | BUS | CYC | FEL | MDZ | NIF | QUI | SIL | SIM | |
| Cimetidine (800–1200)a | 1.1 | 1.8 | 1.8 | 1.5 | 1.6 | ||||
| Clarithromycin (500)a | 3.6 | 2.3 | |||||||
| Clarithromycin (1000)a | 8.4 | 10.0 | |||||||
| Diltiazem (60–120)a | 5.5 | 1.4 | 3.8 | 1.4 | 1.5 | 2.0 | |||
| Erythromycin (800–1000)a | 3.4 | 1.0 | 2.8 | ||||||
| Erythromycin (1500)a | 6.0 | 2.2 | 2.5 | 4.0 | 6.2 | ||||
| Fluconazole (200) | 1.8 | 3.6 | |||||||
| Fluvoxamine (100–200) | 2.4 | 1.7 | 1.4 | 1.4 | |||||
| Grapefruit juice (RS)a | 2.0 | 1.6 | 2.0 | 2.0 | 1.0 | 1.2 | 3.6 | ||
| Grapefruit juice (DS)a | 9.2 | 6.0 | 1.5 | 13.5 | |||||
| Itraconazole (100) | 4.2 | 5.8 | 2.5 | ||||||
| Itraconazole (200) | 16.9 | 1.4 | 6.3 | 6.6 | 18.6 | ||||
| Ketoconazole (200) | 6.8 | 6.1 | 11.8 | ||||||
| Ketoconazole (400) | 11.0 | 12.4 | |||||||
| Mibefradil (50–100)a | 2.3 | 8.9 | |||||||
| Ranitidine (300) | 1.5 | 1.2 | |||||||
| Ritonavir (500 b.i.d.)a | 13.6 | 11.0 | |||||||
| Saquinavir (600–1200 t.i.d.)a | 5.1 | 3.1 | |||||||
| Verapamil (80)a | 3.4 | 1.5 | 2.9 | 1.5 | 4.6 | ||||
BUD, budesonide; BUS, buspirone; CYC, cyclosporine; FEL, felodipine; MDZ, midazolam; NIF, nifedipine; QUI, quinidine; SIL, sildenafil; SIM, simvastatin; RS, regular-strength; DS, double-strength.
↵a Time-dependent inactivator of CYP3A4.