TABLE 1

Comparison of CLu_int corrected for CYP3A abundance in liver and intestine for one HIM and three HLM pools

Data obtained for 22 CYP3A4 substrates represent the individual clearance and the average clearance of all HIM and HLM batches together with the associated coefficient of variation. The clearance values determined in the HLM 1 pool represented 75% (65, 84, 95% CI) of the clearance determined in the HLM 2 pool and 56% (50, 62, 95% CI) of the clearance determined in the HLM 3 pool, whereas the HLM 2 pool represented 77% (72, 82, 95% CI) of the HLM 3 pool. Clearance values for triazolam, alprazolam, and quinidine were taken from Galetin and Houston (2006).

Substrate	CLu_int
Substrate	HIM	HLM			Mean (All)	CV
	μl/min/pmol CYP3A					%
		1	2	3
Alfentanil	0.950	0.550	0.737	1.33	0.890	37
Atorvastatin	0.272	0.279	0.296	0.573	0.355	41
Buspirone	2.17	1.60	1.47	2.12	1.84	19
Cisapride	2.74	1.77	1.56	2.45	2.13	26
Cyclosporine	0.396	0.228	0.598	0.675	0.474	43
Felodipine	23.4	8.40	13.5	16.6	15.5	41
Indinavir	6.00	2.60	3.90	4.70	4.30	32
Lovastatin	48.8	18.8	31.6	42.2	35.4	37
Methadone	0.072	0.105	0.152	0.177	0.126	37
Midazolam	6.80	1.70	2.70	3.80	3.75	58
Nifedipine	2.20	1.90	1.70	2.20	2.00	14
Nisoldipine	76.7	27.0	54.0	54.5	53.1	38
Repaglinide	0.472	0.594	0.865	1.02	0.737	34
Rifabutin	0.516	0.319	0.577	0.642	0.514	27
Saquinavir	60.7	42.4	38.8	63.2	51.3	24
Sildenafil	1.12	0.87	1.05	1.23	1.07	14
Simvastatin	69.6	36.1	47.6	53.7	51.7	27
Tacrolimus	13.2	2.7	7.0	10.4	8.33	54
Terfenadine	33.0	19.2	20.2	27.2	24.9	26
Trazodone	0.236	0.323	0.414	0.505	0.37	31
Verapamil	2.36	1.30	2.22	2.87	2.19	30
Zolpidem	0.022	0.070	0.104	0.144	0.085	61

CV, coefficient of variation.