Route | Dose | Matrix | Parameter | Value |
---|---|---|---|---|
Intravenous | 1.6 mg/kg | Plasma | CL (l/h/kg) | 0.22 |
Plasma | Vdss (l/kg) | 0.65 | ||
Plasma | Half-life (h) | 4.1 | ||
Urine | % of dose excreted as intact SGX523 | 0.2 | ||
Oral | 6.2 mg/kg | Plasma | Cmax (μM) | 4.8 |
Plasma | %F | 39 | ||
Urine | Concentration of SGX523 (μM) | 0.4 | ||
Urine | Concentration of M11 (μM) | 29.2 |