TABLE 4 Effects of Kampo extract medicine (Senkyu-cha-cho-san) on the permeability of digoxin
Papp, AB and Papp, BA values show the apparent permeability of digoxin through the Caco-2 monolayer from the apical-to-basal and basal-to-apical direction, respectively. Initial concentration of digoxin was adjusted to 10 μM. A standard regimen of Kampo extract medicine (Senkyu-cha-cho-san) was prepared by adding 1 package (2.5 g) of Kampo extract medicine to 200 ml of transport medium, vigorously stirring for 2 h, and filtering with filter paper. For the diluted regimen, the standard regimen solution obtained was diluted with TM to adjust to one-fifth or one-tenth concentration of Kampo extract medicine in the standard regimen. Each value represents the mean ± S.E. (n = 3–6).