Calculated contributions of CYP1A2, CYP2C19, and CYP3A4 to the generation of each ramelteon metabolite
| Metabolite | Percentage Liver Microsomal CL′int | Percentage Contribution to Specific Metabolite | Percentage Contribution to Total Hepatic Clearance | ||||
|---|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C19 | CYP3A4 | CYP1A2 | CYP2C19 | CYP3A4 | ||
| A | 34 | 98 | 2 | 0.01 | 33 | 0.68 | 0.003 |
| B | 4.4 | 30 | 70 | N.D. | 1.3 | 3.1 | N.D. |
| C | 5.3 | N.D. | N.D. | 100 | N.D. | N.D. | 5.3 |
| D | 4.3 | 74 | 15 | 11 | 3.2 | 0.64 | 0.47 |
| E | 20 | 24 | 71 | 5 | 4.8 | 14 | 1.0 |
| F | 30 | 22 | 78 | 0.3 | 6.6 | 23 | 0.09 |
| G | 1.7 | 0.6 | 0.5 | 99 | 0.01 | 0.01 | 1.68 |
| H | 0.34 | 45 | 29 | 26 | 0.15 | 0.1 | 0.088 |
| Total | 100 | 49 | 42 | 8.6 | |||