Predictions of DDIs for ketoconazole, fluconazole, and fluvoxamine on ramelteon in humans
| Ketoconazole (200 mg b.i.d.) | Fluconazole (200 mg daily) | Fluvoxamine (100 mg b.i.d.) | |
|---|---|---|---|
| Fold decrease in liver CYP1A2 CL′int | 1.01 | 1.02 | 94 |
| Fold decrease in liver CYP2C19 CL′int | 1.02 | 11 | 10 |
| Fold decrease in liver CYP3A4 CL′int | 18 | 9.1 | 1.12 |
| Fold decrease in intestinal CYP3A4 CL′int | 8200 | 24 | 3.7 |
| Fh,inh/Fh | 1.11 | 1.89 | 8.1 |
| Fg,inh/Fg | 1.64 | 1.58 | 1.41 |
| Predicted DDI | 1.82 | 2.99 | 11.4 |
| Actual DDI | 1.82 | 2.36 | 128 |