TABLE 2

Plasma protein binding and blood/plasma ratio data used in scaling

Drug	Plasma f_u	Blood/Plasma Ratio
O⁶-Benzylguanine	0.10	0.74
Carbazeran	0.08	0.7
DACA	0.021^{^a}	0.85
6-Deoxypenciclovir	1	1.2
Methotrexate	0.66	1
PF-945863	0.54	1.1
PF-4217903	0.16	0.9
RS-8359	0.49	1
XK-469	0.0036^{^a}	0.52
Zaleplon	0.49	0.74
Zoniporide	0.34	0.75

↵a Plasma protein binding acquired from literature (Kestell et al., 1999; Alousi et al., 2007).