TABLE 3

Human pharmacokinetic data for drugs metabolized by aldehyde oxidase

Drug	CL_po or CL_tot	% of CL by Routes Other Than Aldehyde Oxidase	CL′_int,AO	Reference
	ml/(min · kg)		ml/(min · kg)
O⁶-Benzylguanine	14.5^{^a}	0	360	(Dolan et al., 1998)
Carbazeran	1800^{^b}	0	∼13,000	(Kaye et al., 1984)
DACA	17^{^a}	0	3600	(Kestell et al., 1999)
6-Deoxypenciclovir	118^{^b}^,^{^c}	0	140	(Filer et al., 1994)
Methotrexate	2.1^{^b}	80	0.44	(Kristensen et al., 1975; Seideman, 1993)
PF-945863	108^{^b}	0	180	Pfizer, Inc., data on file
PF-4217903	6^{^b}	0	46	Pfizer, Inc., data on file
RS-8359	8.0^{^b}	10	23	(Puchler et al., 1997)
XK-469	0.11^{^a}	2	16	(Alousi et al., 2007)
Zaleplon	16^{^a}	30	65	(Rosen et al., 1999)
Zoniporide	21^{^a}	21	180	(Dalvie et al., 2010)

↵a From intravenous data.
↵b From oral data.
↵c Assumes all dosed famciclovir is converted to 6-deoxypenciclovir by esterases.