TABLE 1

Characteristics of hepatocytes and their donors and formation of mercapturic acids^a

Sample No.	Gender	Age	BMI	Race	Smoker	Alcohol User	CDNB Activity (nmol CDNB conjugate/min/mg total protein)	GSTM1 Expression	GSTA1 Expression	rev BPDE-7-NAC (pmol/ml)^{^b}
										12 h		24 h
										Peak 1	Peak 2	Peak 1	Peak 2
1065	F	69	31	Caucasian	No	No	42	+	+	ND	0.34	0.28	10.1
1066	F	44	20	Caucasian	No	Yes	46		+	ND	ND	0.08	0.12
1071	M	54	24	African-American	No	No	25		+	0.01	0.05	0.17	0.72
1072	F	66	30	Caucasian	Yes	No	42		+	0.04	0.14	0.22	1.29
1075	F	40	35	Caucasian	No	No	45	+	+	ND	0.24	0.1	2.4
1078	M	66	28	Caucasian	No	No	43		+	ND	ND	0.07	0.16
1081	F	56	25	Caucasian	No	No	111		+	ND	ND	0.17	0.33
1085	F	43	27	Caucasian	No	No	163	+	+	0.06	1.89	0.43	17
1088	M	58	22	Caucasian	Yes	Yes	74		+	0.04	0.06	0.07	0.18
1091	M	47	30	Caucasian	No	Yes	61	+	+	ND	0.005	ND	0.19
Mean ± S.D.^{^c}		54 ± 11	27 ± 4.5				65.2 ± 41.8			0.017 ± 0.23	0.30 ± 0.61	0.18 ± 0.12	3.59 ± 5.95

BMI, body mass index; F, female; ND, not detected; M, male.
↵a Hepatocytes were incubated with 10 μM BPDE or rev-BPDE, except sample 1091 (1 μM).
↵b BPDE-10-NAC was detected in only one sample, no. 1085, 0.015 (12 h) and 0.035 (24 h) pmol/ml.
↵c Means for rev-BPDE-7-NAC are based on the nine samples in which the concentration of rev-BPDE was 10 μM.