Pharmacodynamic parameters of GDC-0941 for inhibition of Akt and PRAS40 phosphorylation estimated from a single dose of GDC-0941 in MCF7.1 tumor-bearing mice
| Parametera | pAkt | pPRAS40 |
|---|---|---|
| IC50 (μM) | 0.36 (25.5) | 0.29 (26.0) |
| kin (fluorescence intensity/h) | 89620 (30.5) | 4465 (23.9) |
↵a Parameters are presented as estimates (% coefficient of variation).