Pharmacology Tests | Compounds | |||
---|---|---|---|---|
M1 (Isolated Metabolite) | M1a-1 (R-Enantiomer) | M1a-2 (S-Enantiomer) | Compound 1 | |
nM | ||||
PI3K-α | 4 | 4 | 9 | 8 |
PI3K-γ | 33 | 50 | 93 | 51 |
mTOR | 0.80 | N/A | N/A | 0.50 |
PC3 | 0.08 | 0.04 | 0.06 | 0.02 |
MDA361 | 0.03 | 0.02 | 0.05 | 0.04 |
PI3K, phosphoinositide 3-kinase; mTOR, mammalian target of rapamycin; PC3, prostate cancer cell line; MDA361, human breast adenocarcinoma cell line.