Stability of acyl glucuronides of muraglitazar and peliglitazar in buffer and human plasma incubations at 50 μg/ml and 37°C
The buffer was 50 mM sodium phosphate, pH 7.4. Plasma samples were buffered with 50 mM phosphate, pH 7.4.
N.A., not applicable.
↵a t1/2 was calculated from initial rates of glucuronide disappearance (t1/2 = 0.693/slope).
↵b The value was the average of formation rates within the linear ranges (<3 h).