TABLE 1

Kinetic parameters for 4-MU O-glucuronidation by UGT1A3 and imipramine N-glucuronidation by UGT1A4 expressed in HEK293 cells

Data represent the mean ± S.D. (n = 3).

UGT IsoformGlucuronidationKmVmax
mMpmol/(min · mg protein)
UGT1A34-MU O-glucuronidation0.3 ± 0.0640.4 ± 92.1
UGT1A4Imipramine N-glucuronidation1.1 ± 0.2240.9 ± 02.9