Tissue | Apixaban | |||||
---|---|---|---|---|---|---|
0.5 h | 1 h | 4 h | 8 h | 24 h | 72 h | |
μg Eq/g | ||||||
Adrenal gland | 0.59 | 1.20 | 0.76 | 0.17 | N.S. | N.S. |
Blood | 0.42 | 1.18 | 0.60 | 0.08 | N.S. | N.S. |
Bone marrow | 0.26 | 0.57 | 0.32 | 0.07 | N.S. | N.S. |
Brain | 0.05 | BLQ | BLQ | BLQ | BLQ | BLQ |
Brown fat | 0.46 | 0.94 | 0.53 | 0.07 | N.S. | N.S. |
Harderian gland | 0.21 | 0.69 | 0.42 | 0.12 | N.D. | N.D. |
Heart | 0.33 | 0.70 | 0.45 | 0.08 | N.D. | N.D. |
Kidney (cortex) | 0.81 | 1.72 | 1.36 | 0.88 | BLQ | N.D. |
Liver | 0.81 | 1.72 | 1.36 | 0.39 | BLQ | N.D. |
Lung | 0.57 | 0.70 | 0.64 | 0.14 | BLQ | N.D. |
Muscle | 0.20 | 0.43 | 0.27 | 0.06 | BLQ | N.D. |
Pancreas | 0.47 | 0.62 | 0.55 | 0.12 | BLQ | N.D. |
Pituitary gland | 0.26 | 0.59 | 0.37 | 0.07 | N.D. | N.D. |
Salivary gland | 0.30 | 0.72 | 0.54 | 0.13 | BLQ | N.D. |
Spleen | 0.18 | 0.32 | 0.28 | 0.09 | N.D. | N.D. |
Thymus | 0.16 | 0.46 | 0.23 | 0.06 | N.D. | N.D. |
N.S., not sampled because not visualized on autoradiograph, considered as BLQ; N.D., not detectable; BLQ, below limit of quantitation (0.037 μg Eq/g tissue).