TABLE 2

SB-649868 and total radioactivity plasma pharmacokinetic parameters after a single oral administration of [14C]SB-649868 at a target dose of 30 mg

Data are geometric mean (95% CI) unless otherwise indicated.

ParameterSB-649868Total Radioactivity
n88
AUC(0–∞) (μg · h/ml)a8.30 (5.90, 11.7)37.3 (31.0, 44.8)
AUC(0–t) (μg · h/ml)a8.20 (5.80, 11.5)31.0 (25.0, 38.4)
Cmax (μg/ml)a1.20 (1.00, 1.50)1.66 (1.40, 2.00)
tmax (h)b4.00 (3.00, 4.00)4.00 (3.00, 6.00)
t1/2 (h)4.80 (4.10, 5.80)39.3 (33.4, 46.3)
CL/F (ml/h)3610 (2570, 5070)NC

  • CI, confidence interval; CL/F, systemic plasma clearance/bioavailability; NC, not calculated.

  • ↵a Concentration units for total radioactivity are microgram-equivalents per milliliter.

  • ↵b Median (range).