TABLE 4

Relative distribution of radioactive metabolites in pooled human bile (3–8 h), urine (0–240 h), and feces (0–240 h) after a single oral administration of 10 mg of [¹⁴C]peliglitazar

Metabolite^{^a}	Relative Distribution
	Group 1		Group 2
	Feces	Urine	Bile	Feces	Urine
	% dose
M1	14.6	Trace^{^b}	0.36	4.66	Trace
M2	0.88	0.16			Trace
M3	4.38	0.16		1.79	Trace
M4	6.66	Trace		2.15	Trace
M5	0.88	Trace		0.90	Trace
M6	1.58	Trace			Trace
M7	6.13	Trace		2.33	Trace
M8	1.23			Trace	Trace
M10	5.52			1.63
M14		0.20	16.0		Trace
M14a			0.29		Trace
M14b			3.34
M15			1.0
M15a			0.48
M15b			Trace
M17			1.8		Trace
Parent	47.2	Trace	0.46	18.4	Trace
Other	4.58			0.01
Total	93.7	1.47	23.8	31.9	1.35

↵a Metabolites M9, M11, M12, M13, and M16 were observed in animal samples but not in human samples.
↵b Metabolite was detected by LC-MS but in trace amounts by radioactivity.