TABLE 1

Effects of 16 compounds on bilirubin glucuronidation and estradiol-3-glucuronidation

NameConc.aIC50
Bilirubin Glucuronidation (Effect)Estradiol-3-Glucuronidation (Effect)
μM
Ritonavir1.3–503.0 (inhibition)1.7 (inhibition)
Anthraflavic acid2–403.6 (inhibition)4.0 (inhibition)
Levothyroxine0.6–104.9 (inhibition)5.6 (inhibition)
Baicalein0.5–107.0 (inhibition)4.4 (inhibition)
Farnesol13–6047 (inhibition)40 (inhibition)
4-Methylumbelliferone28–550100 (inhibition)100 (inhibition)
4′-OH-phenytoin15–300120 (inhibition)110 (inhibition)
Raltegravir25–200170 (inhibition)190 (inhibition)
Riluzole25–500180 (inhibition)160 (inhibition)
1-Naphthol88–1700240 (inhibition)280 (inhibition)
Ketoconazole6.3–10027 (inhibition)13 (inhibition)
Carvedilol2.5–5027 (inhibition)12 (inhibition)
Niflumic acid2–8053 (inhibition)13 (inhibition)
SN-386.3–400360 (inhibition)N.A. (partial inhibition)
Ethinylestradiol2.5–5021 (inhibition)44 (activation and inhibition)
Daidzein6.3–1307.3 (inhibition)120 (activation and inhibition)
  • a Concentration ranges of the modifiers used for IC50 determination.