Parameters | M1 | M2 |
---|---|---|
AUC0–t (μg/ml · h) | 2.09 ± 0.33** | 0.427 ± 0.054 |
AUC0–∞ (μg/ml · h) | 2.28 ± 0.49** | 0.466 ± 0.086 |
MRT0–t (h) | 1.24 ± 0.14** | 0.597 ± 0.035 |
MRT0–∞ (h) | 1.76 ± 0.52** | 0.767 ± 0.140 |
t1/2 (h) | 1.57 ± 0.75* | 0.514 ± 0.140 |
CL (l · h/kg) | 2.94 ± 0.54** | 14.3 ± 2.5 |
V (l/kg) | 6.34 ± 2.50* | 10.3 ± 1.6 |
Cmax (μg/ml) | 2.06 ± 0.25** | 0.560 ± 0.070 |