Pharmacokinetic parameters of M1 and M2 after intravenous of 6.5 mg/kg luteolin to rats

Data are expressed as the mean ± S.D. n = 5.

ParametersM1M2
AUC0–t (μg/ml · h)2.09 ± 0.33**0.427 ± 0.054
AUC0–∞ (μg/ml · h)2.28 ± 0.49**0.466 ± 0.086
MRT0–t (h)1.24 ± 0.14**0.597 ± 0.035
MRT0–∞ (h)1.76 ± 0.52**0.767 ± 0.140
t1/2 (h)1.57 ± 0.75*0.514 ± 0.140
CL (l · h/kg)2.94 ± 0.54**14.3 ± 2.5
V (l/kg)6.34 ± 2.50*10.3 ± 1.6
Cmax (μg/ml)2.06 ± 0.25**0.560 ± 0.070

  • ↵ P < 0.05; comparison between two groups with Student's t test.

  • ↵ P < 0.01.