Enzyme kinetics of ticagrelor metabolite formation in recombinant CYP3A4 and CYP3A5 enzymes

Parameter	Formation of AR-C124910XX		Formation of AR-C133913XX
Parameter	CYP3A4	CYP3A5	CYP3A4	CYP3A5
V_max (pmol/min/pmol)	2.17 ± 0.31	0.38 ± 0.03	2.22 ± 0.42	0.38^{^b}
K_m (μM)	11.0 ± 2.5	5.36 ± 1.27	41.3 ± 12.5	127^{^b}
n^{^a}	1.9

↵ Hill factor; others were fitted using the Michaelis-Menten equation.
↵ The estimated K_m value is above the highest concentration tested (50 μM).