Compound | Plasma CL (ml · min−1 · kg−1) | Vss (l/kg) | F | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mouse | Rat | Monkey | Dog | Mouse | Rat | Monkey | Dog | Mouse | Rat | Monkey | Dog | |
Ketoprofen | 4.28 | 0.749 | 4.92 | 1.19 | 0.640 | 0.418 | 0.252 | 0.278 | 1.00 | 0.95 | 0.73 | 1.00 |
Imipramine | 90.0 | 55.2 | 53.1 | 29.2 | 14.1 | 10.5 | 9.69 | 5.95 | 0.01 | 0.07 | 0.02 | 0.07 |
Lorazepam | 13.0 | 5.20 | 13.8 | 18.6 | 13.9 | 0.995 | 1.21 | 6.95 | 1.00 | 1.00 | 0.18 | 0.05 |
Levofloxacin | 79.6 | 7.82 | 7.02 | 2.04 | 5.59 | 3.63 | 1.90 | 1.33 | 1.00 | 0.92 | 0.57 | 1.00 |
Zidovudine | 60.4 | 16.5 | 37.9 | 7.53 | 2.26 | 1.20 | 1.19 | 1.13 | 0.95 | 0.76 | 0.54 | 1.00 |
Diclofenac | 5.33 | 6.67 | 10.2 | 2.45 | 0.458 | 0.643 | 0.210 | 0.590 | 0.59 | 0.69 | 0.59 | 1.00 |
Furosemide | 11.5 | 4.77 | 4.78 | 17.3 | 0.388 | 0.234 | 0.162 | 0.562 | 1.00 | 0.58 | 0.58 | 0.68 |
Raloxifene | 90.0 | 55.2 | 18.9 | 35.8 | 10.7 | 9.44 | 3.41 | 2.90 | 0.22 | 0.04 | 0.03 | 0 |
Gemfibrozil | 3.35 | 1.77 | 5.77 | 2.27 | 0.332 | 0.281 | 0.160 | 1.57 | 0.73 | 0.86 | 0.86 | 0.75 |
Mycophenolic acid | 4.19 | 1.86 | 3.85 | 4.95 | 1.80 | 0.424 | 0.668 | 1.20 | 0.93 | 0.67 | 0.67 | 0.71 |
Indomethacin | 0.253 | 6.36 | 3.86 | 3.92 | 0.170 | 1.85 | 1.79 | 5.58 | 1.00 | 0.92 | 1.00 | 1.00 |
Telmisartan | 9.34 | 6.47 | 2.82 | 6.75 | 9.23 | 2.00 | 1.54 | 2.72 | 1.00 | 1.00 | 0.940 | 1.00 |