TABLE 4

Observed and predicted values of human CL

All these values were quoted from the literature as follows: ketoprofen (Jamali and Brocks, 1990; Obach et al., 2008); imipramine (Shibata et al., 2002; Obach et al., 2008); lorazepam (Shibata et al., 2002); levofloxacin (Chien et al., 1997; Obach et al., 2008); zidovudine (Moore et al., 1995; Obach et al., 2008); diclofenac (Willis et al., 1979; Obach et al., 2008); furosemide (McCrindle et al., 1996; Obach et al., 2008); raloxifene (Heringa, 2003); gemfibrozil (Todd and Ward, 1988; Soars et al., 2002); mycophenolic acid (Bullingham et al., 1998); indomethacin (Alván et al., 1975; Cubitt et al., 2009); and telmisartan (Stangier et al., 2000b; Obach et al., 2008).

CompoundPlasma CL (ml · min−1 · kg−1)Plasma CLpo (ml · min−1 · kg−1)
Observed ValuesPrediction by AllometryPrediction by SSSObserved ValuesPrediction for CL by Allometry and Fa × Fg fromPrediction by SSS and Fa × Fg from
MouseRatMonkeyDogMouseRatMonkeyDogMouseRatMonkeyDog
Ketoprofen1.600.7880.8220.1892.041.221.740.8170.8470.9830.8170.8010.1852.531.22
Imipramine13.012.712.110.625.321.531.069316430998.938674.4859166
Lorazepam1.215.272.201.338.6622.11.217.197.1921.77.192.141.2436.3319
Levofloxacin1.901.078.741.454.591.871.901.131.161.831.137.931.025.701.30
Zidovudine25.04.2311.94.0523.16.1033.35.185.975.185.1822.35.09NC7.45
Diclofenac3.501.070.7840.7413.461.116.481.801.541.431.151.811.467.841.69
Furosemide1.601.921.150.6151.435.332.122.213.673.512.211.771.503.5912.0
Raloxifene14.77.2011.810.47.0526.073510.797.7876NC24.1173805NC
Gemfibrozil1.701.010.5110.3903.111.701.731.411.211.081.280.9180.5965.163.02
Mycophenolic acid3.310.9640.4900.3321.312.933.541.081.491.391.170.7670.7112.836.04
Indomethacin1.583.310.07371.571.723.791.583.863.863.863.860.07521.731.914.73
Telmisartan8.401.182.941.561.454.5617.81.241.241.241.242.681.351.244.48
Percentage of compounds within
    2-fold33424258502525422533335033
    3-fold58585083674250585042506742
    4-fold75675083835050585850506758
  • NC, not calculated.