Liver extraction ratio, bioavailability, hepatic clearance, volume of distribution, total clearance, and metabolite/parent AUC ratio for finasteride after intravenous and intrajejunal administration with (T2) and without (T1) ketoconazole coadministration
| Parameter | T1 | T2 | Parameter | Intravenous |
|---|---|---|---|---|
| EHa | 0.5 ± 0.2 | 0.3 ± 0.1 | EHa | 0.2 ± 0.1 |
| CLH (ml · min−1 · kg−1)a | 25 ± 11 | 18 ± 5 | EHb | 0.1 ± 0.01 |
| F (VF)c | 0.4 ± 0.2 | 0.9 ± 0.1* | CL (ml · min−1 · kg−1)b | 7 ± 1 |
| F (VF)d | 0.4 ± 0.3 | 1.1 ± 0.1* | Vss (liters) | 25 ± 0.5 |
| Vss (l/kg) | 0.99 ± 0.04 | |||
| AUCM3/AUCfinasteride | AUCM3/AUCfinasteride | |||
| VP | 0.9 ± 1.2 | 0.04 ± 0.02 | VP | 0.12 ± 0.04 |
| VH | 3.1 ± 5.3 | 0.1 ± 0.05 | VH | 0.20 ± 0.04 |
| VF | 1.4 ± 1.6 | 0.06 ± 0.02 | VF | 0.11 ± 0.03 |