TABLE 4

Biliary excretion, apparent biliary clearance, and comparison bile/plasma ratio of finasteride and M3 after intravenous and intrajejunal administration with (T2) and without (T1) ketoconazole coadministration

	Finasteride			M3
	T1	T2	Intravenous	T1	T2	Intravenous
A_{e(bile, 0–6 h)} (μmol)	0.05 ± 0.05	0.09 ± 0.03	0.02 ± 0.01	1.7 ± 1.3	0.6 ± 0.4	0.8 ± 0.8^{^a}
	0.03 (0.002–0.12)^{^b}	0.09 (0.05–0.13)^{^b}	0.02 (0.01–0.04)^{^b}	1.2 (0.7–3.9)^{^b}	0.7 (0.05–1.3)^{^b}	0.6 (0.06–1.65)^{^b}
f_bile (%)	0.09 ± 0.09	0.18 ± 0.07	0.19 ± 0.10	3.1 ± 2.4	1.1 ± 0.8	5.5 ± 5.7
CL_{app, bile} (ml · min⁻¹ · kg⁻¹)	0.009 ± 0.007	0.010 ± 0.004	0.014 ± 0.006	2.4 ± 1.3	1.2 ± 0.4	3.6 ± 3.4
AUC_{bile, 0–6 h} (μM · h)	2.5 ± 1.9	4.2 ± 2.0	1.1 ± 0.5	106 ± 63	27 ± 20	23 ± 20
C_max (μM)	1.3 ± 1.0	2.0 ± 0.9	0.5 ± 0.04	37 ± 25	9.5 ± 7.2	8.2 ± 9.3
AUC_bile/AUC_VP^{^c}	0.9 ± 0.6	0.7 ± 0.3	0.9 ± 0.3	106 ± 74	104 ± 69	174 ± 134
AUC_bile/AUC_VH^{^c}	14 ± 12	6 ± 3	7 ± 2	94 ± 67	69 ± 35	136 ± 103
Biliary flow (ml · min⁻¹ · kg⁻¹)	0.010 ± 0.004	0.016 ± 0.008	0.015 ± 0.006

↵a ID8 had very low amount of excreted finasteride-ω-oic-acid (M3).
↵b Data are median (range).
↵c Plasma AUC for finasteride was corrected for f_u = 0.17.