Renal excretion and renal clearance of finasteride and M3 after intravenous and intrajejunal administration with (T2) and without (T1) ketoconazole coadministration
| Finasteride | M3 | |||||
|---|---|---|---|---|---|---|
| T1 | T2 | Intravenous | T1 | T2 | Intravenous | |
| Ae(urine, 0–6 h) (μmol) | 0.01 ± 0.01 | 0.04 ± 0.02* | 0.02 ± 0.02 | 8.5 ± 5 | 3.4 ± 5a | 1.2 ± 1 |
| furine (%) | 0.02 ± 0.01 | 0.08 ± 0.04* | 0.12 ± 0.11 | 16 ± 9 | 6 ± 9 | 9 ± 9 |
| CLrenal (ml · min−1 · kg−1) | 0.005 ± 0.002 | 0.006 ± 0.003 | 0.010 ± 0.011 | 4.0 ± 2.2 | 6.7 ± 8.1 | 6.5 ± 6.6 |
| Urinary flow (ml · min−1 · kg−1) | 0.016 ± 0.004 | 0.024 ± 0.010 | 0.039 ± 0.043 | |||