Mean intravenous and oral plasma clearance data, number of subjects, blood/plasma ratios, and fraction unbound in plasma for drugs investigated

References for all the clinical data are listed in the supplemental data.

Observed In Vivo Plasma ClearanceaRBbfupNo. Subjects
ml · min1 · kg1
Quercetin5.2 (0.6–12)391 (1.55–62381)10.011046
Raloxifene14.7c735 (735–831)10.05N.A.>1000
Salbutamol8.4 (7.6–9.3)16.6 (12.6–22.9)10.9254851
Troglitazone2.512.8 (5.3–14.6)0.550.01N.A.>250
  • N.A., no subject information available.

  • a Data are weighted mean (range). For salbutamol, weighted renal clearance was 4.8 and 4.3 ml · min−1 · kg−1 after intravenous and oral administration, respectively. Renal clearance was negligible for other drugs.

  • b Assumed to be 1 for basic drugs and 0.55 for acidic drugs.

  • c Calculated from oral clearance data (735 ml · min−1 · kg−1) and reported bioavailability of 2% (Hochner-Celnikier, 1999; Mizuma, 2009).