TABLE 3

Kinetic parameters of gemfibrozil-related compounds to predict the DDI between pravastatin and gemfibrozil

Inhibitory effect of gemfibrozil-related compounds on the uptake of pravastatin by human kidney slices was examined. K_i values were determined by nonlinear regression analysis and are represented as the mean ± S.D.

	K_i	C_max	f_u^{^a}	C_{max, u}	R
	μM	μM
Gemfibrozil	1.47 ± 0.48	100–150^{^b,^c}	0.00648	0.65–0.97	0.60–0.69
Gemfibrozil M3	3.97 ± 1.49	24^{^d}	0.0123	0.30	0.93
Gemfibrozil glucuronide	9.05 ± 8.43	20^{^c}	0.115	2.3	0.80

↵a Data from Shitara et al. (2004).
↵b Data from Backman et al. (2002).
↵c Data from Okerholm et al. (1976).
↵d Data from Nakagomi-Hagihara et al. (2007).