Pharmacokinetic data for NSAIDs and paracetamol

DrugDosageCmaxCmaxCport vnReferencea
Acetylsalicylic acid50013.6120205Acetylsalicylic acid (aspirin) product information, Bayer Vital GmbH (Leverkusen, Germany, 2009)1
Diclofenac5021.52515Diclofenac (Voltaren) product information, Novartis Pharma GmbH (Nürnberg, Germany 2010)2
Ibuprofen4003393187316Ibuprofen (Urem forte) product information, Dr. Kade Pharmazeutische Fabrik GmbH (Berlin, Germany, 2010)3
Lumiracoxib10042.44831Mysler (2004)4
Naproxen2 × 2505875379524Zhou et al. (1998)5
Paracetamol50069660280Paracetamol (Paracetamol-ratiopharm) product information, ratiopharm GmbH (Ulm, Germany, 2008)6
Salicylic acidb500 (ASA)1201126334
  • ASA, acetylsalicylic acid; Cmax, maximal plasma concentration in the systemic circulation; Cport vn, predicted concentration in portal venous blood [according to Ito et al. (1998)].

  • a Superior numbers link data with reference.

  • b Calculated on the basis of a single 500-mg dose of acetylsalicylic acid.