Comparison of OATP1B1- and OATP1B3-mediated pravastatin uptake kinetics in the absence and presence of the NSAIDs diclofenac and lumiracoxib
| Without NSAID | OATP1B1 | OATP1B3 | ||
|---|---|---|---|---|
| Km | Vmax | Km | Vmax | |
| μM | pmol × mg protein−1 × min−1 | μM | pmol × mg protein−1 × min−1 | |
| 10 μM diclofenac | 135.1 | 85.8 | 24.3 | 15.9 |
| 10 μM lumiracoxib | 317.7 | 147.5 | 52.4 | 29.0 |