mRNA levels measured in hepatocytes treated with IL-6
Donor Hu1153 was treated with IL-6 for 72 h. Data were normalized to untreated values.
| P450 Isoform | EC50 | Emax | Emin | Hill Slope | R2 |
|---|---|---|---|---|---|
| pg/ml | % treated cells | ||||
| 1A1 | 1620 | 93.1 | 37.2 | −1.05 | 0.91 |
| 1A2 | 271 | 101 | 15.7 | −1.03 | 0.98 |
| 2B6 | 70.0 | 95.4 | 3.11 | −0.95 | 0.98 |
| 2C8 | 153 | 84.1 | 3.86 | −0.82 | 0.97 |
| 2C9 | 121 | 95.6 | 5.25 | −0.88 | 0.98 |
| 2C19 | 71.3 | 101 | 21.4 | −0.90 | 0.96 |
| 2D6 | 151 | 103 | 30.2 | −0.75 | 0.96 |
| 3A4 | 3.23 | 157 | 0 | −0.77 | 0.99 |
| 3A5 | 51.0 | 85.8 | 3.43 | −0.93 | 0.98 |
| 4A11 | 160 | 105 | 2.47 | −1.16 | 0.96 |