Time-dependent suppression of acetaminophen and 6β-hydroxytestosterone formation in IL-6-treated hepatocytes
Donor Hu1153 was used in this study. Data were normalized to untreated values.
| Time Point | EC50 | Emax | Emin | Hill Slope | R2 |
|---|---|---|---|---|---|
| pg/ml | % treated cells | ||||
| Acetaminophen formation | |||||
| 48 h | 409 | 90.3 | 10.7 | −1.5 | 0.98 |
| 72 h | 443 | 99.1 | 12.5 | −1.3 | 0.99 |
| 96 h | 1260 | 94.1 | 23.3 | −1.7 | 0.96 |
| 6β-Hydroxytestosterone formation | |||||
| 48 h | 56.3 | 84.1 | 41.6 | −1.3 | 0.90 |
| 72 h | 20.6 | 96.5 | 28.6 | −0.9 | 0.94 |
| 96 h | 17.1 | 97.5 | 21.5 | −0.8 | 0.98 |