CLuint | CVa | |||
---|---|---|---|---|
HIMb | HLMb | HJM Meana | ||
μl · min−1 · mg−1 | % | |||
Atorvastatin | 13.6 | 59.3 | 33.5 | 47 |
Buspirone | 108 | 268 | 142 | 60 |
Cyclosporine | 27.7 | 79.5 | 53.5 | 66 |
Felodipine | 1170 | 1990 | 1610 | 51 |
Indinavir | 298 | 582 | 645 | 47 |
Lovastatin | 2440 | 4790 | 2740 | 59 |
Midazolam | 340 | 429 | 418 | 47 |
Nisoldipine | 3840 | 7000 | 6180 | 47 |
Saquinavir | 3030 | 7460 | 7220 | 65 |
Simvastatin | 3480 | 7100 | 5840 | 41 |
Tacrolimus | 658 | 1040 | 1970 | 67 |
Terfenadine | 1650 | 3440 | 3690 | 59 |
a Data from the present study; for tacrolimus, CLuint value represents the mean and CV of seven individual intrinsic clearance values.
b CLuint data from HIM pool (n = 10 donors) and three HLM pools (n = 105 donors in total) reported in Gertz et al. (2010).