TABLE 1

Inhibitory effects (IC50) of NBuPy-Cl and structurally related ILs on OCT-mediated TEA or metformin transport

Data are means ± S.E.M., n = 3 to 5.

ILsIC50
hOCT2rOCT1: TEArOCT2: Metformin
TEAMetformin
μM
BmPy-Cl0.48 ± 0.05**0.15 ± 0.01*,#4.70 ± 1.371.80 ± 0.26**
Bmim-Cl1.50 ± 0.430.44 ± 0.047.53 ± 0.971.81 ± 0.08**
Py-Cl790 ± 51**555 ± 40**,#762 ± 254*671 ± 92**
EtPy-Cl36.7 ± 3.7*20.1 ± 2.2*,#72.1 ± 13.3*14.4 ± 0.9**
NBuPy-Cl2.29 ± 0.640.69 ± 0.08#4.74 ± 0.663.78 ± 0.23
HePy-Cl0.35 ± 0.03**0.10 ± 0.01*,#2.21 ± 0.23*0.10 ± 0.01**
  • * P < 0.05 and ** P < 0.01, compared with NBuPy-Cl.

  • # P < 0.05, compared with the probe substrate of TEA for hOCT2.