Metformin concentration in selected tissues of F-344 rats after intravenous administration of metformin (5 mg/kg) to male F-344 rats infused with saline or NBuPy-Cl
Data are presented as means ± S.E.M. [tissue (g)/plasma (ml) metformin concentration ratio].
| NBuPy-Cl | Metformin Concentration | ||
|---|---|---|---|
| 0 (Saline) (n = 4) | 0.5 mg/kg per hour (n = 4) | 2 mg/kg hour (n = 4) | |
| μg/g tissue | |||
| Adipose | 4.2 ± 2.3 [4.6] | 1.8 ± 0.4 [1.5] | 7.3 ± 0.9 [3] |
| Heart | 41.3 ± 4.4 [56] | 31.6 ± 2.5 [25] | 45.8 ± 8.4 [19] |
| Kidneys | 204 ± 73 [213] | 151 ± 47 [121] | 756 ± 192 [266] |
| Liver | 16.9 ± 2.9 [21] | 13.7 ± 0.3 [11] | 44.9 ± 11.1 [16] |
| Lung | 14.5 ± 2.7 [19] | 15.0 ± 0.8 [12] | 28.7 ± 4.8 [11] |
| Muscle | 7.1 ± 2.0 [8.8] | 5.8 ± 0.4 [4.7] | 12.8 ± 1.2 [5.4] |
| Spleen | 8.8 ± 1.6 [11] | 8.5 ± 0.5 [6.8] | 18.3 ± 3.4 [7] |
| Testes | 3.9 ± 0.3 [5.3] | 4.6 ± 0.4 [3.7] | 7.4 ± 1.2 [2.9] |