TABLE 2

Salivary APAP pharmacokinetics and urinary APAP metabolite excretion by diet and UGT1A6 genotypes within diet

Data are least squares means ± S.E.

	Overall			UGT1A61/1		UGT1A61/2		UGT1A62/2
	Basal	F&V	P^*	Basal	F&V	Basal	F&V	Basal	F&V
Salivary pharmacokinetics
n	65	65		27	27	25	25	13	13
C_max (mg/l)	16.1 ± 0.6	17.5 ± 0.7	0.003	17.2 ± 0.9	18.3 ± 1.0	15.1 ± 0.9	16.0 ± 0.9	16.0 ± 1.3^{^a}	18.4 ± 1.5^{^b}
Clearance (1/h)	10.0 ± 0.5	9.9 ± 0.5	0.88	9.3 ± 0.7^‡	9.5 ± 0.7	11.9 ± 0.9^†	10.5 ± 0.8	9.1 ± 1.0^‡	9.8 ± 1.1
AUC (mg · min/l)	6103 ± 270	6155 ± 272	0.88	6414 ± 419	6326 ± 408	5378 ± 369	5692 ± 387	6588 ± 613	6478 ± 611
t_1/2 (min)	260 ± 15	282 ± 16	0.17	261 ± 22	281 ± 23	245 ± 22	285 ± 25	275 ± 33	279 ± 34
Urinary APAP metabolite excretion
n	65	65		27	27	25	25	13	13
% oral does
%APAP	3.1 ± 0.12	3.2 ± 0.12	0.25	3.37 ± 0.16	3.53 ± 0.16^†	2.91 ± 0.16	3.00 ± 0.16^‡	2.95 ± 0.23	2.98 ± 0.23^‡
%APAPG	35.0 ± 0.9	35.8 ± 0.9	0.17	32.9 ± 1.4	34.7 ± 1.4	35.4 ± 1.4	36.3 ± 1.4	36.7 ± 2.0	36.6 ± 2.0
%APAPS	24.1 ± 0.9	22.1 ± 0.9	<0.0001	25.0 ± 1.3^{^a}	23.2 ± 1.3^{^b}	25.0 ± 1.3^{^a}	22.9 ± 1.3^{^b}	22.5 ± 1.9^{^a}	20.1 ± 1.9^{^b}
Metabolite ratios
APAPG ratio^{^c}	56.2 ± 1.2	58.9 ± 1.2	<0.0001	53.5 ± 1.7^{^a}	56.7 ± 1.7^{^b}	56.1 ± 1.8^{^a}	58.7 ± 1.8^{^b}	58.9 ± 2.5^{^a}	61.2 ± 2.5^{^b}
APAPG/APAP^*	11.8 ± 0.6	11.9 ± 0.6	0.83	10.0 ± 0.7	10.1 ± 0.7^†	12.7 ± 0.9	12.9 ± 0.9^‡	13.2 ± 1.3	12.9 ± 1.3^‡
APAPS/APAP	8.1 ± 0.4	7.1 ± 0.3	<0.0001	7.5 ± 0.5^{^a}	6.6 ± 0.4^{^b}	8.7 ± 0.6^{^a}	7.9 ± 0.5^{^b}	8.1 ± 0.8^{^a}	7.0 ± 0.7^{^b}

* Significant overall diet effect for UGT1A6 genotype (P < 0.05).
†,‡ <ths>Different superscript numbers represent significant genotype differences within diet (P < 0.05).
a,b Different superscript letters represent significant diet differences within a genotype (P < 0.05).
c APAPG/(APAP + APAPG + APAPS) × 100.