TABLE 2

Kinetic parameters of metformin in male F-344 rats after intravenous administration (5 mg/kg) with NBuPy-Cl or saline infusion

Data are means ± S.E.M.; n = 3 to 4. Predicted parameters were calculated using noncompartment model analysis.

NBuPy-Cl	AUC0_180	t_1/2	CL	V_ss
	min · μg/ml	h	ml/min	ml
0 (saline)	358 ± 47	2.3 ± 0.6	3.4 ± 1.0	484 ± 47
0.5 mg/kg per hour	391 ± 37	2.8 ± 0.4	2.3 ± 0.2	473 ± 22
2 mg/kg per hour	687 ± 86^*	4.5 ± 1.2	1.2 ± 0.4^*	334 ± 22

AUC0_180, area under the curve from 0 to 180 min; t_1/2, elimination half-life; CL, systemic clearance; V_ss, volume of distribution.
* P < 0.05, compared with saline group.