TABLE 2

Kinetic parameters of metformin in male F-344 rats after intravenous administration (5 mg/kg) with NBuPy-Cl or saline infusion

Data are means ± S.E.M.; n = 3 to 4. Predicted parameters were calculated using noncompartment model analysis.

NBuPy-ClAUC0_180t1/2CLVss
min · μg/mlhml/minml
0 (saline)358 ± 472.3 ± 0.63.4 ± 1.0484 ± 47
0.5 mg/kg per hour391 ± 372.8 ± 0.42.3 ± 0.2473 ± 22
2 mg/kg per hour687 ± 86*4.5 ± 1.21.2 ± 0.4*334 ± 22
  • AUC0_180, area under the curve from 0 to 180 min; t1/2, elimination half-life; CL, systemic clearance; Vss, volume of distribution.

  • * P < 0.05, compared with saline group.