TABLE 4

In vitro parameters

Compound	k_mem	Rat f_{med, ss}	Dog f_{med, ss}	fu_inc	fu_L	Dog PPB	Rat PPB	Dog B/P	Rat B/P
Ibuprofen	0	0.98	0.98	0.97	0.25	98.8	97.7	0.6	0.6
Indomethacin	0.20	0.65	0.70	0.78	0.08	99.2	99.7	0.6	0.6
Losartan	0.05	0.32	0.67	0.87	0.08	95.2	98.5	1	0.8
Ramatroban	0.22	0.42	0.58	0.71	0.08	95.5	96.3	0.6	0.8
Sulfisoxazole	0.05	0.84	0.80	0.77	0.51	86.6	98.4	0.6	0.6
Telmisartan	0.004	0.33	0.41	0.51	0.04	97.9	99.4	0.9	0.9
Tolmetin	0.04	0.96	0.96	0.96	0.31	95.0	97.1	1.1	1
AZ1	0.14	0.27	0.45	0.80	0.08	99.7	99.7	0.6	0.7
AZ2	0.08	0.25	0.42	0.90	0.06	99.6	99.6	0.6	0.6

f_{med, ss}, fraction in the medium at steady state; fu_inc, fraction unbound in the incubation; fu_L, fraction unbound in liver tissue; PPB, plasma protein binding; B/P, blood/plasma ratio.