TABLE 3

Volume of distribution of tissues in rat and dog

Mean values of two animals (rat) and one animal (dog) from tissue homogenate prepared in triplicate.

Compound	Species	V_t			V_ss
Compound	Species	Liver	Muscle	Plasma	V_ss
		l/kg
Ibuprofen	Rat	0.008	0.04	0.14	0.18
Indomethacin	Rat	0.007	0.01	0.14	0.16
Losartan	Rat	2.5	0.005	0.14	2.62
Ramatroban	Rat	1.2	0.15	0.14	1.46
Sulfisoxazole	Rat	0.002	0.02	0.14	0.16
Telmisartan	Rat	3.3	0.02	0.14	3.44
Tolmetin	Rat	0.01	0.03	0.14	0.18
AZ1	Rat	1.7	0.02	0.14	1.86
AZ2	Rat	0.5	0.02	0.14	0.71
Ibuprofen	Dog	0.08	0.06	0.14	0.19
Losartan	Dog	0.07	<LOQ	0.14	0.25
Telmisartan	Dog	0.004	0.005	0.14	0.32