TABLE 2

Observed in vivo parameters in bile duct-cannulated rats and dogs

All data represent individual animals or mean ± S.D. of a minimum of three animals.

Compound	Species	Clearance				V_ss
Compound	Species	Total	Metabolic	Biliary	Renal	V_ss
		ml · min⁻¹ · kg⁻¹				l/kg
Ibuprofen	Rat	2.4, 1.5	2.4, 1.5	0, 0	0.002, 0.001	0.2, 0.2
Indomethacin	Rat	0.2, 0.3	0.2, 0.3	0.0009, 0.0007	0.0001, 0.0001	0.1, 0.1
Losartan	Rat	4.3, 5.0	4.1, 4.4	0.2, 0.6	0.0004, 0.0005	2.0, 1.2
Ramatroban	Rat	17, 14	15, 13	1.7, 0.6	0.001, 0.002	1.3, 1.3
Sulfisoxazole	Rat	0.1, 0.1	0.1, 0.1	0.001, 0.001	0.009, 0.009	0.2, 0.2
Telmisartan	Rat	6.0, 7.5	5.8, 7.3	0.2, 0.2	0, 0	2.4, 2.7
Tolmetin	Rat	1.5 ± 0.4	1.5 ± 0.4	0, 0	0.024 ± 0.006	0.11 ± 0.03
AZ1	Rat	6.0 ± 2.6	5.6 ± 2.4	0.4 ± 0.2	0.006 ± 0.003	0.9 ± 0.2
AZ2	Rat	8.0 ± 2.3	6.1 ± 1.8	1.6 ± 0.5	0.3 ± 0.1	0.6 ± 0.3
Ibuprofen	Dog	0.5, 0.7	0.5, 0.7	0.0004, 0.0007	0.0005, 0.0002	0.08, 0.07
Indomethacin	Dog	4.0, 2.3	3.8, 2.1	0.3, 0.2	0.0004, 0.0003	0.09, 0.05
Losartan	Dog	27, 44	24, 34	0.3, 6.6	2.8, 3.2	0.4, 0.3
Ramatroban	Dog	9.8 ± 4.8	7.6 ± 3.4	1.1 ± 1.2	1.1 ± 1.0	2.2 ± 1.4
Sulfisoxazole	Dog	1.6 ± 0.8	0.2 ± 0.2	0.0005 ± 0.0009	1.4 ± 0.9	0.3 ± 0.1
Telmisartan	Dog	6.1, 4.0	4.1, 2.3	1.9, 1.7	0.002, 0.002	0.7, 0.4
Tolmetin	Dog	0.4, 0.8	0.3, 0.7	0.004, 0.009	0.009, 0.1	0.1, 0.4
AZ1	Dog	1.9, 1.0	1.5, 0.8	0.1, 0.2	0.3, 0.1	0.2, 0.4
AZ2	Dog	1.2, 2.4	0.9, 2.0	0.3, 0.3	0.05, 0.07	0.4, 0.3